Spencer Ware has overcome a lot of hardships to make himself a starting running back in the NFL. He entered the league as a sixth-round pick to the Seattle Seahawks. With Seattle, Ware would only last one season, in which he would only get three rushing attempts.

Following his rookie year, Ware was released by the Seahawks and went the entire 2014 season without a team. In December 2014, he signed a futures contract with the Kansas City Chiefs. In the 2015 season, Ware acted as the backup running back to Jamaal Charles. As a result, he got limited playing time. In 2015, Ware became the full-time starter for the Chiefs, getting 921 yards and three touchdowns on 4.3 yards per carry.

In the 2016 pre-season, Ware suffered a season-ending injury. Ware would not become the Chiefs starter again until mid-way through the 2018 season after Kareem Hunt was released. This past season, Ware had 51 rushes for 246 yards and two touchdowns.