The Redskins will be without one of their listed starting linebackers in Perry Riley Jr. and Andre Roberts, while Chris Thompson is among four players that are questionable for the game.
Washington Redskins head coach Jay Gruden confirmed on Friday afternoon that linebacker Perry Riley Jr. (foot) and wide receiver Andre Roberts (knee) will not play Sunday against the Buffalo Bills.
This is the third straight week that Riley Jr. will be out, as he suffered a foot injury during one of the team's practices leading up to their Week 13 Monday Night Football matchup with the Dallas Cowboys.
Mason Foster has taken his place in the starting lineup over the last two weeks, recording 13 tackles and a forced fumble.
Roberts, meanwhile, could be facing surgery for a meniscus issue he's been dealing with recently.
"We're just trying to see if he can finish the season with it or if he has to go have surgery," Gruden said on Thursday. "I think we'll make that determination here shortly."
If Roberts can't go at all for the rest of the season, he will finish 2015 with 11 receptions for 135 yards along with seven kickoff returns for 231 yards and a touchdown.
With Roberts definitely unable to go this weekend, the team will once again rely on Rashad Ross as its primary kick returner.
The Arizona State product is currently fourth in the NFL in kickoff return yards with 615.
Additionally, Gruden announced that defensive end Jason Hatcher (knee), safety Jeron Johnson (hamstring), running back Chris Thompson (shoulder) and linebacker Keenan Robinson (shoulder) will be listed as questionable.
Hatcher did not practice on Wednesday – a customary day off for the veteran – but was limited on Thursday and Friday.
The 10-year Grambling State product has appeared in all 13 games this season as he leads a defensive end rotation that also includes Ricky Jean Francois, Chris Baker and Frank Kearse.
Check out images of veteran defensive end Jason Hatcher during the 2015 offseason.
Johnson did not play last Sunday against the Chicago Bears and was limited in practice this week.
While he battled Duke Ihenacho for a starting role at strong safety – a position Ihenacho would win – Johnson now backs up defensive back DeAngelo Hall, who recently moved away from cornerback.
Thompson was limited throughout this week's practice as he tries to work his way back from a torn labrum.
"So, you know, I found out last Monday what was wrong with me," Thompson told Redskins.com on Thursday. "Came in Tuesday I couldn't even lift my arm hardly, had a sling on. Then Wednesday just had a miraculous recovery, really. I was able to lift my arm up above my head in a day's time, so just one of those things where I just got to continue to progress and get it better and just make the right decisions for myself."
Thompson said that if he can play, he'll wear a harness to protect his shoulder.
Robinson has been active the past two games, but hasn't recorded a single defensive snap.
Linebacker Will Compton (shoulder), safety Dashon Goldson (wrist/knee), wide receiver Ryan Grant (abdomen), defensive back DeAngelo Hall (toe) and tackle Trent Williams (foot) were all listed on the injury report this week -- practicing in either a limited or full capacity.
Wide receiver DeSean Jackson (knee) will be listed as probable as he practice on Thursday and Friday after not participating in Wednesday's session.