Clinton Portis broke his right hand in the first half of Sunday's 27-3 loss to the Philadelphia Eagles, and he will require surgery that could sideline him for several weeks.
The team will update Portis's status on Monday.
Portis suffered the injury late in the first quarter on a run play behind left tackle. Portis appeared to injure his hand when he stiff-armed Eagles' free safety Brian Dawkins before getting knocked out of bounds.
Earlier in the game, Portis also suffered a neck injury, but he was able to return to action.
Portis finished the game with six carries for 25 yards.
He was replaced by Ladell Betts, who rushed for 83 yards on 20 carries. T.J. Duckett also had two carries for 16 yards.
"We're going to miss Clinton, but we'll be all right," fullback Mike Sellers said.
For Portis, the fractured hand was the latest injury in a season where he has struggled to stay healthy. He suffered a shoulder injury during preseason, which lingered into the regular season and forced him to sit out the Week 2 game at Dallas. He also suffered an ankle injury in Week 7 against Indianapolis.
Last week, Portis discussed his injury concerns at length with reporters.
"This year has been difficult," Portis said. "I've had some real awkward falls. If I can make it through this year, I'll be happy. But just having this opportunity and fighting with my team--I am going to be all right."
Asked if this season has been the most frustrating of his career as a result of the injuries, Portis replied: "It is frustrating, but I am at one with myself. I am happy right now. I love being a part of this organization."