Clinton Portis and Jason Taylor are among Redskins players expected to sit out Sunday night's Hall of Fame Game against the Indianapolis Colts.
Chris Samuels, London Fletcher, LaRon Landry, Carlos Rogers, Rocky McIntosh and Malcolm Kelly are also unlikely to play against the Colts.
Head coach Jim Zorn said that the Redskins will play "some starters" in the preseason opener, but the goal of the game is to get a look at younger players.
Those starters who do play will probably see limited action.
"It is not just that we do not want to risk injury," Zorn said. "It's that we also have a lot of younger players we need to look at.
"The younger players are going to get a great opportunity to go out and show what they can do to earn the right to be part of this team."
Some veterans, such as Portis, Taylor and Fletcher, are being held out of the game to keep them healthy for the regular season.
Asked if Portis had an injury, Zorn replied: "Clinton is not dinged up at all. He has some tight hip flexors, but he can take the rest. We just really have to get Rock Cartwright and Marcus Mason ready because they are going to take the bulk of the work in the run game."
Regarding Taylor, Zorn said: "He just started training camp. If he got in, it would be very minimal [playing time]. It would be in a pass rush situation. But I don't think that's going to happen."
Samuels, Betts, Rogers, McIntosh and Landry are coming off of injuries.
Samuels is easing into training camp after off-season elbow surgery, while Rogers and McIntosh have just started to return to action from knee ligament injuries.
Betts sustained a thigh contusion during practice earlier this week and he said he would not play vs. Indianapolis.
Landry has been slowed in the last week by a hamstring injury.
"LaRon is almost back [for practice], but we are not going to play him in the game," Zorn said. "We are going to continue to rehab him, and I think the extra days will help his recovery."
On Thursday, Kelly tried to come back from a hamstring injury, but Zorn said he "really labored."
Anthony Mix also has a hamstring injury. He said on Thursday that his injury was "feeling better," but he was uncertain if he would be available to play.
With so many wide receivers injured, Maurice Mann, Burl Toler and Horace Gant are expected to see plenty of action in the second half of the game.
Zorn said he would also periodically spread tight ends out as wide receivers in some formations.
Anthony Montgomery (fractured hand), Rian Wallace (fractured hand), H.B. Blades (knee), Erasmus James (knee) and Devin Thomas (hamstring) have already been ruled out for Sunday's game.
Chris Wilson, sidelined earlier this week due to a calf injury, might be available to play.